Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic
Identifieur interne : 000168 ( Main/Exploration ); précédent : 000167; suivant : 000169Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic
Auteurs : Alain Gagnon [Canada] ; Enrique Acosta [Canada] ; Stacey Hallman [Canada] ; Robert Bourbeau [Canada] ; Lisa Y. Dillon [Canada] ; Nadine Ouellette [Canada] ; David J. D. Earn [Canada] ; D. Ann Herring [Canada] ; Kris Inwood [Canada] ; Joaquin Madrenas [États-Unis] ; Matthew S. Miller [Canada]Source :
- mBio [ 2150-7511 ] ; 2018.
Descripteurs français
- KwdFr :
- Facteurs de risque, Grippe humaine (immunologie), Grippe humaine (mortalité), Grippe humaine (virologie), Humains, Mexique (épidémiologie), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Susceptibilité à une maladie, États-Unis d'Amérique (épidémiologie).
- MESH :
- immunologie : Grippe humaine, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A.
- mortalité : Grippe humaine.
- virologie : Grippe humaine.
- épidémiologie : Mexique, États-Unis d'Amérique.
- Facteurs de risque, Humains, Susceptibilité à une maladie.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Mexico, United States.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza, Human.
- mortality : Influenza, Human.
- virology : Influenza, Human.
- Disease Susceptibility, Humans, Risk Factors.
Abstract
Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world. Those who have survived infections with influenza viruses in the past have been protected from subsequent antigenically similar pandemics through adaptive immunity. For example, during the 2009 H1N1 “swine flu” pandemic, those exposed to H1N1 viruses that circulated between 1918 and the 1940s were at a decreased risk for mortality as a result of their previous immunity. It is also generally thought that past exposures to antigenically dissimilar strains of influenza virus may also be beneficial due to cross-reactive cellular immunity. However, cohorts born during prior heterosubtypic pandemics have previously experienced elevated risk of death relative to surrounding cohorts of the same population. Indeed, individuals born during the 1890 H3Nx pandemic experienced the highest levels of excess mortality during the 1918 “Spanish flu.” Applying Serfling models to monthly mortality and influenza circulation data between October 1997 and July 2014 in the United States and Mexico, we show corresponding peaks in excess mortality during the 2009 H1N1 “swine flu” pandemic and during the resurgent 2013–2014 H1N1 outbreak for those born at the time of the 1957 H2N2 “Asian flu” pandemic. We suggest that the phenomenon observed in 1918 is not unique and points to exposure to pandemic influenza early in life as a risk factor for mortality during subsequent heterosubtypic pandemics.
Url:
DOI: 10.1128/mBio.02091-17
PubMed: 29339427
PubMed Central: 5770550
Affiliations:
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Le document en format XML
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xml:lang="fr">Canada</country><wicri:regionArea>Department of Demography, Université de Montréal, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Université de Montréal Public Health Research Institute (IRSPUM), Montréal, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal Public Health Research Institute (IRSPUM), Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Acosta, Enrique" sort="Acosta, Enrique" uniqKey="Acosta E" first="Enrique" last="Acosta">Enrique Acosta</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Demography, Université de Montréal, Montréal, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Demography, Université de Montréal, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Hallman, Stacey" sort="Hallman, Stacey" uniqKey="Hallman S" first="Stacey" last="Hallman">Stacey Hallman</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Statistics Canada, Ottawa, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Statistics Canada, Ottawa</wicri:regionArea><wicri:noRegion>Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Bourbeau, Robert" sort="Bourbeau, Robert" uniqKey="Bourbeau R" first="Robert" last="Bourbeau">Robert Bourbeau</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Demography, Université de Montréal, Montréal, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Demography, Université de Montréal, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Dillon, Lisa Y" sort="Dillon, Lisa Y" uniqKey="Dillon L" first="Lisa Y." last="Dillon">Lisa Y. Dillon</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Demography, Université de Montréal, Montréal, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Demography, Université de Montréal, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Ouellette, Nadine" sort="Ouellette, Nadine" uniqKey="Ouellette N" first="Nadine" last="Ouellette">Nadine Ouellette</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Demography, Université de Montréal, Montréal, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Demography, Université de Montréal, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Earn, David J D" sort="Earn, David J D" uniqKey="Earn D" first="David J. D." last="Earn">David J. D. Earn</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Department of Mathematics and Statistics, McMaster University, Hamilton, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Mathematics and Statistics, McMaster University, Hamilton</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Michael G. DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Michael G. DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Herring, D Ann" sort="Herring, D Ann" uniqKey="Herring D" first="D. Ann" last="Herring">D. Ann Herring</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Department of Anthropology, McMaster University, Hamilton, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anthropology, McMaster University, Hamilton</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Inwood, Kris" sort="Inwood, Kris" uniqKey="Inwood K" first="Kris" last="Inwood">Kris Inwood</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Economics and Finance, Department of History, University of Guelph, Guelph, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Economics and Finance, Department of History, University of Guelph, Guelph</wicri:regionArea><wicri:noRegion>Guelph</wicri:noRegion></affiliation></author><author><name sortKey="Madrenas, Joaquin" sort="Madrenas, Joaquin" uniqKey="Madrenas J" first="Joaquin" last="Madrenas">Joaquin Madrenas</name><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Los Angeles Biomedical Research Institute at Harbor, UCLA Medical Center, Los Angeles, California, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Los Angeles Biomedical Research Institute at Harbor, UCLA Medical Center, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Miller, Matthew S" sort="Miller, Matthew S" uniqKey="Miller M" first="Matthew S." last="Miller">Matthew S. Miller</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Michael G. DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Michael G. DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff9"><addr-line>Department of Biochemistry and Biomedical Sciences, McMaster Immunology Research Centre, McMaster University, Hamilton, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry and Biomedical Sciences, McMaster Immunology Research Centre, McMaster University, Hamilton</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease Susceptibility</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (mortality)</term><term>Influenza, Human (virology)</term><term>Mexico (epidemiology)</term><term>Risk Factors</term><term>United States (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Facteurs de risque</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (mortalité)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Mexique (épidémiologie)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Susceptibilité à une maladie</term><term>États-Unis d'Amérique (épidémiologie)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Mexico</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Mexique</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Susceptibility</term><term>Humans</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term><term>Humains</term><term>Susceptibilité à une maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world. Those who have survived infections with influenza viruses in the past have been protected from subsequent antigenically similar pandemics through adaptive immunity. For example, during the 2009 H1N1 “swine flu” pandemic, those exposed to H1N1 viruses that circulated between 1918 and the 1940s were at a decreased risk for mortality as a result of their previous immunity. It is also generally thought that past exposures to antigenically dissimilar strains of influenza virus may also be beneficial due to cross-reactive cellular immunity. However, cohorts born during prior heterosubtypic pandemics have previously experienced elevated risk of death relative to surrounding cohorts of the same population. Indeed, individuals born during the 1890 H3Nx pandemic experienced the highest levels of excess mortality during the 1918 “Spanish flu.” Applying Serfling models to monthly mortality and influenza circulation data between October 1997 and July 2014 in the United States and Mexico, we show corresponding peaks in excess mortality during the 2009 H1N1 “swine flu” pandemic and during the resurgent 2013–2014 H1N1 outbreak for those born at the time of the 1957 H2N2 “Asian flu” pandemic. We suggest that the phenomenon observed in 1918 is not unique and points to exposure to pandemic influenza early in life as a risk factor for mortality during subsequent heterosubtypic pandemics.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Earn, Djd" uniqKey="Earn D">DJD Earn</name></author><author><name sortKey="Dushoff, J" uniqKey="Dushoff J">J Dushoff</name></author><author><name sortKey="Levin, Sa" uniqKey="Levin S">SA Levin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Ms" uniqKey="Miller M">MS Miller</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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sort="Dillon, Lisa Y" uniqKey="Dillon L" first="Lisa Y." last="Dillon">Lisa Y. Dillon</name><name sortKey="Earn, David J D" sort="Earn, David J D" uniqKey="Earn D" first="David J. D." last="Earn">David J. D. Earn</name><name sortKey="Earn, David J D" sort="Earn, David J D" uniqKey="Earn D" first="David J. D." last="Earn">David J. D. Earn</name><name sortKey="Gagnon, Alain" sort="Gagnon, Alain" uniqKey="Gagnon A" first="Alain" last="Gagnon">Alain Gagnon</name><name sortKey="Hallman, Stacey" sort="Hallman, Stacey" uniqKey="Hallman S" first="Stacey" last="Hallman">Stacey Hallman</name><name sortKey="Herring, D Ann" sort="Herring, D Ann" uniqKey="Herring D" first="D. Ann" last="Herring">D. Ann Herring</name><name sortKey="Inwood, Kris" sort="Inwood, Kris" uniqKey="Inwood K" first="Kris" last="Inwood">Kris Inwood</name><name sortKey="Miller, Matthew S" sort="Miller, Matthew S" uniqKey="Miller M" first="Matthew S." last="Miller">Matthew S. Miller</name><name sortKey="Miller, Matthew S" sort="Miller, Matthew S" uniqKey="Miller M" first="Matthew S." last="Miller">Matthew S. Miller</name><name sortKey="Ouellette, Nadine" sort="Ouellette, Nadine" uniqKey="Ouellette N" first="Nadine" last="Ouellette">Nadine Ouellette</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Madrenas, Joaquin" sort="Madrenas, Joaquin" uniqKey="Madrenas J" first="Joaquin" last="Madrenas">Joaquin Madrenas</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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